AMD Radeon cards don't work in current time

Use a clean installation. Unzip archive into folder with original game without previous versions of q2xp or other mods. Owners of Creative audio cards can remove openAl32.dll from the game folder. The renderer requires full support for OpenGL 4.5 with GL_ARB_bindless_texture and GL_ARB_texture_storage support.
https://www.moddb.com/mods/quake-2-xp/downloads/q2xp-1269-covid-edition
Whats New? (1.26.9 full changes list)

New extended save system
Save shots in save-load game menu
High DPI scale fix
HRTF audio mode (openal soft)
Openal resampler control (openal soft)
Separate fx and music levels
Fix music looping
Fix mission paks music
Sound outputs for all available system audio devices
Better hardware info in console
Russian language support for console and menu messages with utf8 to win1251 conversion
xBox controller: individual sens and dedzone for left and right sticks
sRGB color frame buffer for better game gamma-contrast
Player weapon reflections (md3 only)
Speedup md3 shadows
Global fog and in-game fog editor
3D luts for color grading
Color temperature control
Sub surface scatering lighting for md3 meshes
Rework ejection of cartridges (new models)
Update and cleanup FXAA code
Cubemap skyboxes
Bindless textures (AZDO rendering tech)
Better md3 lighting, fixed md3 degenerate triangles lighting (crappy tbn)
New screen flash effect
New memory manager (thx to Berserker)
Rescaled menus, fonts etc for 4k resolution
Blurred glass surfaces
Diffraction surfaces for alias models
Softeness parallax shadows

More engine fixes etc....

Апдейт который много что правит тут
https://www.moddb.com/mods/quake-2-xp/downloads/q2xp-1269-update-1